Robert Neville may be a top scientist, but even he could not prevent the spread of a dangerous virus that was developed by humans and cannot be cured. For some unknown reason, Neville is immune to the virus and is the only member of the human race living in the ruins of New York City. He may even be the last living human on the planet. For three years, day after day, he's been broadcasting his message on the air, searching for more survivors.
But Neville is not alone. Watching him from the shadows are the mutated victims of a worldwide pandemic, watching his every move, waiting for him to make a fatal mistake. Neville, who may well be the world's only hope, is kept alive by a single idea: to reverse the impact of the virus by making a cure from his own blood. But he stands alone against the rest of the world, and time is playing against him...
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