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When Robert Langdon (Tom Hanks) discovers evidence of the resurgence of the ancient secret brotherhood known as the Illuminati - the most powerful secret organization in history - he also faces a mortal danger that threatens the secret organization's most hated enemy: the Catholic Church. When Langdon learns that the clock on the unstoppable time bomb represented by the Illuminati is still ticking, he flies to Rome where he joins forces with Vittoria Vetra (Ayelet Zurer), a beautiful and enigmatic Italian scientist. Langdon and Vetra embark on a nonstop journey and adventure-filled chase set among sealed crypts, dangerous catacombs, abandoned cathedrals and even into the heart of the world's most sealed vault. On their journey, they track 400-year-old ancient symbols that represent the only hope for the Vatican's survival...